Clinical and Translational Sciences

Clinical and Translational Sciences

The Department of Clinical and Translational Sciences (DCTS) was created to foster collaboration and enrichment among clinicians and basic scientists. Permanent and joint-faculty work together within an integrated structure to advance research and therapy options for Central Appalachia.

DCTS is the academic home for the Appalachian Center for Cellular Transport in Obesity Related Disorders (ACCORD) at Marshall University, the Marshall Clinical Research Center, and Marshall Informatics that provides support and resources to researchers, clinicians, and patient advocates working to improve the health of the people of Appalachia. This multidisciplinary department leverages a variety of expertise to address issues through the full spectrum of translational science.

Faculty

Subha Arthur, PhD
Associate Professor

Alip Borthakur, PhD
Assistant Professor

Shelvy L. Campbell-Monroe
Assistant Dean for Diversity & Inclusion

Alfred A. Cecchetti, PhD, MSc, MSc IS
Director, Division of Clinical Informatics (DCI)

Jennifer Haynes
Research Assistant Professor 

Rajan Lamichhane, PhD
Assistant Professor, Bio-statistician

Balasubramanian Palaniappan, PhD
Assistant Professor 

Soudamani Singh, PhD
Assistant Professor

Umapathy Sundaram, MD
Vice Dean, Chairman, DCTS

Joint Faculty

Ji Bihl, PhD
Associate Professor 
bihlj@marshall.edu 

Holly Cyphert, PhD
Assistant Professor 
Damron40@marshall.edu

James Denvir, PhD
Associate Professor
denvir@marshall.edu

Richard Egleton, PhD
Assistant Dean of the Office of Research and Graduate Education, Associate Professor, Research Cluster Coordinator
egleton@marshall.edu

Brandon Henderson, PhD
Associate Professor
hendersonbr@marshall.edu

Jung Han Kim, PhD
Professor
kimj@marshall.edu

Usha Murughiyan, MD
Assistant Dean for Clinical Research 
murughiyan@marshall.edu

Michael Norton
Associate Professor 
bihlj@marshall.edu 

Sundaram

Gary O. Rankin, PhD
Professor & Chair
rankin@marshall.edu

Travis Salisbury, PhD
Associate Professor
salisburyt@marshall.edu

Maria A. Serrat, Ph.D.
Associate Professor
Department of Biomedical Sciences
serrat@marshall.edu

Post Doctoral's
Administration

Rong Fan 
Financial Administrator 
Rong.fan@marshall.edu
Phone: (304) 691-1844

Carlie Harrah
Administrative Assistant 
harrah43@marshall.edu
Phone: (304) 691-1836

Jessica Kraschnewski
Recruitment and Marketing Specialist 
kraschnewsk1@marshall.edu
Phone: (304) 696-7279

Clinical Coordinators

Mary Beth Cordle, MS, Quality
Officer
(304) 691-1081
cordlem@marshall.edu

Nicole Finley
Coordinator
304-691-1830
finley18@marshall.edu


Daniell Gallagher 
Coordinator
304-691-1577
gallagherd@marshall.edu


Gina Finley
Coordinator
304-691-6815
finley22@marshall.edu

Hillary Salava
Coordinator
(304) 691-6859
riegel@marshall.edu


David Coates
Coordinator
(304) 691-1082
coates1@marshall.edu

Jessica Merrick
Coordinator
304-691-5393
cantrell25@marshall.edu

Clinical Informatics

Shifa Khan
Data Warehouse Programmer 
khan106@marshall.edu
Phone: (304) 691-6816


Rajan Lamichhane, PhD
Assistant Professor, Biostatistician
lamichhaner@marshall.edu

Department Publications

Umapathy Sundaram, MD
Chairman
Phone: (304) 691-1841
sundaramu@marshall.edu

For a full listing of publications, please access PubMed.

Mast cell regulation of Na-glutamine co-transporters B0AT1 in villus and SN2 in crypt cells during chronic intestinal inflammation. Singh S, Arthur S, Talukder J, Palaniappan B, Coon S, Sundaram U. Biochim Biophys Acta. 2015 April;10.1186/s12876-015-0275-5

Chronic and selective inhibition of basolateral membrane Na-K-ATPase uniquely regulates brush border membrane Na absorption in intestinal epithelial cells.Manoharan P, Gayam S, Arthur S, Palaniappan B, Singh S, Dick GM, Sundaram U. Dig Dis Sci. 2015 April;308(8):C650-6. doi: 10.1152/ajpcell.00355.2014

Molecular mechanism of regulation of villus cell Na-K-ATPase in the chronically inflamed mammalian small intestine. Saha P, Sundaram U, Manoharan P, Arthur S, Kekuda R, et al. Biochimica et biophysica acta. 2015; 1848(2):702-11.

Subha Arthur, PhD
Associate Professor
arthursu@marshall.edu

For a full listing of publications, please access PubMed.

Molecular mechanism of regulation of villus cell Na-K-ATPase in the chronically inflamed mammalian small intestine. Saha P, Manoharan P, Arthur S, Sundaram S, Kekuda R, Sundaram U. Biochim Biophys Acta. 2015;1838(5):1848(2):702-11. PMID:25462166

Chronic and selective inhibition of basolateral membrane Na-K-ATPase uniquely regulates brush border membrane Na absorption in intestinal epithelial cells. Manoharan P, Gayam S, Arthur S, Palaniappan B, Singh S, Dick G, Sundaram U. American journal of physiology Cell physiology. 2015:ajpcell.00355.2014. Epub 2015/02/06. doi: 10.1152/ajpcell.00355.2014. . PMID: 25652450

Mast cell regulation of Na-glutamine co-transporters B0AT1 in villus and SN2 in crypt cells during chronic intestinal inflammation. Singh S, , Arthur S, Talukder J, Palaniappan B, Coon S, et al. BMC gastroenterology 2015; 15:47. PMID: PMC4405831

Soudamani Singh
PhD
singhs@marshall.edu

For a full listing of publications, please access PubMed.

Chronic and selective inhibition of basolateral membrane Na-K-ATPase uniquely regulates brush border membrane Na absorption in intestinal epithelial cells Manoharan P, Gayam S, Arthur S, Palaniappan B, Singh S, Dick G, Sundaram U.American Journal of Physiology-Cell Physiology. 2015 00355. PMID:25652450

Mast cell regulation of Na-glutamine co-transporters B0AT1 in villus and SN2 in crypt cells during chronic intestinal inflammation Singh S, Arthur S, Talukder J, Palaniappan B, Coon S, Sundaram UBMC Gastroenterol. 2015 Apr 15;15:47. doi: 10.1186/s12876-015-0275-5

Unique regulation of Na-glutamine cotransporter SN2/SNAT5 in rabbit intestinal crypt cells during chronic enteritis.  Singh S, Arthur S, Sundaram U. J Cell Mol Med. 2018 Mar;22(3):1443-1451. doi: 10.1111/jcmm.13257.

Cyclooxygenase pathway mediates the inhibition of Na-glutamine co-transporter B0AT1 in rabbit villus cells during chronic intestinal inflammation. Arthur S, Singh S, Sundaram U. PLoS One. 2018;13(9):e0203552. doi: 10.1371/journal.pone.0203552.

Maria Serrat, PhD
Serrat@marshall.edu

For a full listing of publications, please access PubMed.

Environmental temperature impact on bone and cartilage growth.
Serrat MA. Compr Physiol. 2014 Apr;4(2):621-55. doi: 10.1002/cphy.c130023.
PMID: 24715562 [PubMed - in process]

Hindlimb heating increases vascular access of large molecules to murine tibial growth plates measured by in vivo multiphoton imaging.
Serrat MA, Efaw ML, Williams RM. J Appl Physiol (1985). 2014 Feb 15;116(4):425-38. doi: 10.1152/japplphysiol.01212.2013. Epub 2013 Dec 26. PMID: 24371019 [PubMed - in process]

Allen’s rule revisited: temperature influences bone elongation during a critical period of postnatal development.
Serrat MA. Anat Rec (Hoboken). 2013 Oct;296(10):1534-45. doi: 10.1002/ar.22763. Epub 2013 Aug 19. PMID: 23956063 [PubMed - indexed for MEDLINE]

Alfred Cecchetti, PhD, MSc,
MSc IS
Clinical Informatics Data Architect
ACTSI
Phone: (304) 691-1834
cecchetti@marshall.edu

For a full listing of publications, please access PubMed.

Team building: electronic management-clinical translational research (eM-CTR) systems. Cecchetti AA, Parmanto B, Vecchio ML, Ahmad S, Buch S, Zgheib NK, Groark SJ Jr, Vemuganti A, Romkes M, Sciurba F, Donahoe MP, Branch RA.Clin Transl Sci. 2009 Dec;2(6):449-55. PMID:20443940

Family networks of obesity and type 2 diabetes in rural Appalachia. Pancoska P1, Buch S, Cecchetti A, Parmanto B, Vecchio M, Groark S, Paulsen S, Bardwell G, Morton C, Chester A, Branch R. Clin Transl Sci. 2009 Dec;2(6):413-21. PMID:20443933

Feasibility of adolescents to conduct community-based participatory research on obesity and diabetes in rural Appalachia. Bardwell G, Morton C, Chester A, Pancoska P, Buch S, Cecchetti A, Vecchio M, Paulsen S, Groark S, Branch RA. Clin Transl Sci. 2009 Oct;2(5):340-9. PMID:20443917

Balasubramanian Palaniappan
PhD, Coordinator
palianappan@marshall.edu

For a full listing of publications, please access PubMed.

Chronic and selective inhibition of basolateral membrane Na-K-ATPase uniquely regulates brush border membrane Na absorption in intestinal epithelial cells Manoharan, P., Gayam, S., Arthur, S., Palaniappan, B., Singh, S., Dick, G., & Sundaram, U.American Journal of Physiology-Cell Physiology. 2015 00355. PMID:25652450

Antiviral activity of ancient system of ayurvedic medicinal plant Cissus quadrangularis L. (Vitaceae). Balasubramanian, P., Jayalakshmi, K., Vidhya, N., Prasad, R., Khaleefathullah Sheriff, A., Kathiravan, G., Rajagopal, K. and Sripathi M. Sureban. Journal of Basic and Clinical Pharmacy. 2010;1(1): 37-40.

Mast cell regulation of Na-glutamine co-transporters B0AT1 in villus and SN2 in crypt cells during chronic intestinal inflammation. Singh S, Arthur S, Talukder J, Balasubramanian, P., Coon S, et al. BMC gastroenterology. 2015; 15:47

Rajan Lamichhane, PhD
Assistant Professor, Biostatistician
lamichhaner@marshall.edu

For a full listing of publications, please access PubMed. 

Zhang Q, Lamichhane R, Wright M, et al. Trends in Breastfeeding Disparities in U.S. Infants by WIC Eligibility and Participation. Journal of Nutrition Education and Behavior. 2019; 51 (2), 182-189.

Lamichhane R, Singh S, and Diawara N. Improved estimation of population mean using the known median of auxiliary variable. Communications in Statistics-Simulation and Computation. 2017; 46 (4), 2821-2828.

Vorona RD, Szklo-Coxe M, Lamichhane R, et al. Adolescent crash rates and school start times in two central Virginia counties, 2009-2011: a follow-up study to a southeastern Virginia study, 2007-2008. Journal of clinical sleep medicine. 2014;  10 (11), 1169-1177.

Research Clusters
Clinical Research Center