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Research

The Department of Cardiovascular Disease at Marshall engages in outstanding clinical research activities that span the entire spectrum of cardiovascular therapeutics. Marshall Cardiology encourages fellows to participate in clinical and basic research and also encourage them to present their research at the national cardiovascular conferences. To help facilitate research activities, our program provides fellows with blocks of protected research time and covers the travel cost of presentations for fellows. We have robust collaboration with basic science departments for fellows interested in more “bench” exposure.

Research is a mandatory part of cardiology fellowship training and each fellow is provided with 4-5 months of protected time. Each fellow will complete a mentored, hypothesis-driven research project that will be developed throughout the program, with expectation of at least one publication. Additional research time is available to fellows seeking a career in clinical investigation.

First-year trainees have one month of research. During this month the fellow identifies an area of interest and begins the process of preparing a protocol for a hypothesis-driven small-scale research project, and an IRB application.

There are 2 research months in the second year and 1 or 2 months of research the third year of fellowship. During these months the fellow should have IRB approval for the project and will begin data collection and analysis. Manuscripts should be completed and submitted for publication.

Yearly presentations to Marshall University Research Day and the WV Chapter Meeting of the American College of Cardiology are expected. Our fellows present frequently at national conferences, including American College of Cardiology, Transcatheter Therapeutics, and American Society of Echocardiography.

Publications

Book Chapters

Bobak Mosadegh, Ahmed Amro, Yazan Numan. Multimaterial Cardiovascular Printing: Chapter 10. In "3D Printing Applications in Cardiovascular Medicine" - 1st edition. Copyright © 2018 Elsevier Inc. ISBN: 978-0-12-803917-5

EKG PRIMER: YOUR COMPANION ON THE CARDIOLOGY ROTATION • Mian Bilal Alam, Samir Saba• Case series of 100 challenging EKGs - Publication August 2015. ISBN 978-0692490808 (Available on Amazon.com)

Peer Reviewed Journal Articles/Abstracts

Amro A, Gabi A, Aljoudi H, Sayyed R. Brugada Syndrome: A Rare Life-Threatening Condition. West Virginia Medical Journal. 2017 Nov 1;113(6):32-5.

Srikanthan K, Klug R, Tirona T, Thompson E, Visweshwar H, Puri N, Shapiro J, Sodhi K. Creating a Biomarker Panel for Early Detection of Chemotherapy related Cardiac Dysfunction in Breast Cancer Patients. J Clin Exp Cardiolog 2017 8:507. doi 10.4172/2155-9880.1000507

Shaver A, Nichols, A ,Thompson E, Mallick A, Payne K, Sundaram S, Shapiro JI, Sodhi K. Role of Serum Biomarkers in Early Detection of Diabetic Cardiomyopathy. Int J Med Sci 2016 Feb 5. PMID 26941576

Cao J, Tsenovoy PL, Thompson EA, Falk JR, Touchon R, Sodhi K, Rezzanu R, Shapiro JI, Abraham NG. Agonists of epoxyeicosatrienoic acids reduce infarct size and ameliorate cardiac dysfunction via activation of HO-1 and Wnt1canonical pathway. Prostaglandins and Other Lipid Mediators. 2015 Jan-Mar; 116-117:76-86. Doi: 10.1016/j.prostaglandins.2015.01.002 Epub 2015 Feb 9. PMID 25677507

Tekleyes, FG; Lester, MD; Studeny, MA; Thompson, EA; and Craig, S "An Unusual Migration of A Stent: A Case Report," Marshall Journal of Medicine 2016 Vol. 2: Iss. 2, Article 9. DOI: http://dx.doi.org/10.18590/mjm.2016.vol2.iss2.9

Darrat, YH; Gress, TW; Thompson, EA; Wehner, PS; and Charles, M. "Cardiomyopathy Secondary to Thyroid and Parathyroid Dysfunction: Case Report and Literature Review," Marshall Journal of Medicine 2016 Vol. 2: Iss. 1, Article 3. DOI: http://dx.doi.org/10.18590/mjm.2016.vol2.iss1.3

Thompson, EA; Studeny, MA. "Clinical Images - An Incidental EKG," Marshall Journal of Medicine 2015 Vol. 1: Iss. 1, Article 9. DOI: http://dx.doi.org/10.18590/mjm.2015.vol1.iss1.9
Amro A, Gabi A, Elhamdani S, Aljoudi H, El-Hamdani M. Retrograde Pedal Access For Revascularization Of Infrapopliteal Arterial Occlusive Disease In Critical Limb Ischemia (CLI) Patients As A Primary Approach. Marshall Journal of Medicine. 2016;2(4):8.

Amro A, Gabi A, Elhamdani A, Iqbal N, El-Hamdani M. Retrograde Tibiopedal Access as a Bail-Out Procedure for Endovascular Intervention Complications. Case reports in vascular medicine. 2016;2016.

Amro MD, Gabi MD, El-Hamdani MD, FSCAI D. Endovascular Therapy of TASC-D Lesion in Critical Limb Ischemia. Marshall Journal of Medicine. 2016;2(3):32.

Amro MD, Gabi MD, Khitan MD, Zeid J. Pregnancy Induced Microangiopathy, HELLP OR TTP!. Marshall Journal of Medicine. 2015;1(1):4.

Gabi A, Amro A, Aljoudi H, Hayat F, Sayyed R. Acute Limb Ischemia due to a Fractured Superficial Femoral Artery Stent. Marshall Journal of Medicine. 2016;2(4):64.

Aqtash O, Amro A, Alam B, Sobeih A, Lester M, Sayyed R. Urgent Coronary Artery Bypass Grafting Due to Multi-Vessel Coronary Aneurysm. Marshall Journal of Medicine. 2018;4(2):4.

Amro A, Aqtash O, Hirzallah H, Numan Y, Gabi A, AlKhankan E, Kanbour M, Akpanudo S, Mehiar EH. CRT-100.90 Transradial Coronary Intervention (TCI) Using 5-Fr Versus 6-Fr Guiding Catheters in the Setting of Acute Coronary Syndrome (ACS). JACC: Cardiovascular Interventions. 2018 Feb 26;11(4):S26.

Amro A, Kanbour M, Hirzallah H, Aqtash O, Numan Y, Gabi A, El-hamdani A, Akpanudo S, Mehiar EH. SCAI-Transradial verrsus transfemoral approach for coronary angiography in females with prior bypass surgery). CCI: Catherization and ardiovascular Interventions. 2018 April 1;91(2):S216.

Alkhankan E, Alkhankan H, Bukamur HS, Amro A, Megri MA, Alkhankan F, Zeid FM. Relapsing Pulmonary Alveolar Proteinosis Treated with GM-CSF. InD32. ILD: CASE REPORTS II 2018 May (pp. A6485-A6485). American Thoracic Society.

Alkhankan F, Alkhankan E, Bukamur HS, Alkhankan H, Amro A, Shahoub I, Shweihat YR, Zeid FM. Pulmonary Alveolar Microlithiasis with Satisfactory Diagnosis by Bone Scintigraphy of the Lung. InA40. ILD: CASE REPORTS I 2018 May (pp. A1563-A1563). American Thoracic Society.

Jawaid Y, Shweihat YR, Hirzallah H, Damir K, Aqtash O, Megri MA, Mezughi H, Amro A, Yonus R, Najim A, Todd G. Hyperammonemia a Marker for Sepsis: A Single Arm Clinical Trial. InA49. critical care: looking for clues-biomarkers in ards, sepsis, and acute critical illness 2018 May (pp. A1819-A1819). American Thoracic Society.

Alkhankan H, Alkhankan E, Mezughi H, Megri MA, Bukamur HS, Amro A, Alkhankan F, Zeid FM. Recurrent Sarcoidosis Resembling Splenic Malignancy. InD33. ILD: CASE REPORTS III 2018 May (pp. A6528-A6528). American Thoracic Society.

Amro, A., Gabi, A., & Khitan, Z.. PREGNANCY INDUCED MICROANGIOPATHY, HELLP OR TTP!. American Journal of Kidney Diseases. 2015, Apr; Volume 65(Issue 4): Page A18.

Okoro K. U., Larsen T. R., Lystash J. C. “Systemic Embolization from an Unusual Intra-cardiac Mass in the Left Ventricular Outflow Tract.” Case Reports in Medicine. Vol 2017. Article ID 4513623. DOI: 10.1155/2017/4513623.

Okoro K. U., Roby M. D., Sane D. C., and Budin R. E. “Infiltrating Cardiac Synovial Sarcoma Presenting as Cerebrovascular Accident.“ Case Reports in Medicine. Vol 2017. Article ID 8539606. DOI: 10.1155/2017/8539606

Okoro K. U., Roby M. D., Bankole A. A. “Myocarditis Secondary to Mesalamine-Induced Toxicity in a Patient with Ulcerative Colitis.” Case Reports in Medicine. Vol 2018. Article ID 9813893. DOI: 10.1155/2018/9813893

Okoro K. U., Gomez M. D., Grider D. J., Baffoe-Bonnie A. W. “Tuberculous Enteritis Presenting as Acute Appendicitis and Peri-rectal Abscess.” Case Reports in Medicine. Volume 2018. Article ID 6068258. DOI: 10.1155/2018/6068258

Cauchi M. P., Okoro K. U., Williams E, and Baker J. W. “No Such Thing as a Small Leak: A Case of Cryptogenic Left Ventricular Free Wall Rupture with Tamponade after Elective Percutaneous Coronary Intervention. JACC. Volume 71. Issue 11 Supplement. March 2018. DOI: 10.1016/S0735-1097(18)32771-2

Aljadi A, Elhamadani S, Kanbour M, El-Hamadni M. Coronary Artery Origin Anomalies- Review article. Marshall Journal of Medicine. Volume 3, Issue 3. July 2017 2.

Aljadi A, Baryun E, Recognition and Treatment of Atrial Fibrillation Caused by an Accessory Pathway in A middle Age Patient. Marshall Journal of Medicine. Volume 3 Issue 4. October 2017. 3.

Aljadi A, Somberg J. The Impact Of The Regimented Administration Of Aminophylline Following Regadenoson on The Sensitivity Of SPECT Myocardial Perfusion Imaging: Pooled Analysis Of The ASSUAGE And ASSUAGE-CKD Trials. Rush University, ProQuest Dissertations Publishing, 2014. 1525792

Khattak, F., Alam, M. B., Paul, T. K., Rijal, S., Wazir, S., Lavie, C. J., & Saba, S. ”Antithrombotic Therapy In Nonvalvular Atrial Fibrillation: Consensus And Challenges.” The American Journal of Medical Sciences Volume 355 Issue 5 May 2018 (467-476)

Comparative Effectiveness Of Antiarrhythmic Drugs For Rhythm Control Of Atrial Fibrillation Journal of Cardiology 2016 May;67(5):471-6. doi: 10.1016/j.jjcc.2015.07.001. Epub 2015 Jul 29. PubMed: 26233885

Qin D, Leef G, Alam MB, Rattan R, Munir MB, Patel D, Khattak F, Vaghasia N, Adelstein E, Jain SK, Saba S “Battery Longevity From Cardiac Resynchronization Therapy Defibrillators: Differences Between Manufacturers And Discrepancies With Published Product Performance Reports.” Europace. 2016 March 22. doi.org/10.1093/europace/euw044 PMID: 27009183

Alam MB, Munir MB, Rattan R, Adelstein E, Jain S, Saba S. “Mortality Risk Of Long-Term Amiodarone Therapy For Atrial Fibrillation Patients.” Cardiology Journal 2015;22(6):622-9. doi: 10.5603/CJ.a2015.0055. Epub 2015 Sep 28. PubMed: 26412606

Qin D, Alam MB, Leef G, Rattan R, Munir MB, Patel D, Khattak F, Vaghasia N, Adelstein E, Jain SK, Saba S: “Outcomes Of Sprint Fidelis And Riata Lead Extraction: Data From 2 Highvolume Centers.” Heart Rhythm 2015 Jun;12(6):1216-20. doi: 10.1016/j.hrthm.2015.02.031. Epub 2015 May18. Pubmed: 25998138

El-Chami, MF, Merchant, FM, Levy, M, Alam, MB, Rattan, R., Hoskins, M. H, Saba: “Risk Of Stroke And Death In Atrial Fibrillation By Type Of Anticoagulation: Apropensity-Matched Analysis.” Pacing and Clinical Electrophysiology 2015 Nov;38(11):1310-6. doi: 0.1111/pace.12695. Epub 2015 Aug 7. Pubmed: 26171564

Leef G, Qin D, Althouse A, Alam MB, Rattan R, Munir MB, Patel D, Khattak F, Vaghasia N, Adelstein E, Jain SK, Saba S. “Patient Outcomes According To Adherence To Treatment Guidelines For Rhythm Control Of Atrial Fibrillation.” Journal of the American Heart Association. 2015 Apr 6;4(4). pii: e001793. doi:10.1161/JAHA.115.001793. Pubmed: 25845930

Qin D, Leef G, Alam MB, Rattan R, Munir MB, Patel D, Khattak F, Vaghasia N, Adelstein E1, Jain SK, Saba S. “Interference By Human Anti-Mouse Antibodies In Immunoassays: Falsely Elevated Cardiac Troponins Leading To Negative Coronary Angiograms” Annual Research & Review In Biology. 2015;6(5):323-327

Alam MB, Kumar S, Sbietan I, Hussain KMA, Asad M, Khan. “An Influence Of Qrs Duration On Outcome Of Death Or Appropriate Defibrillator Therapy By Strategy Of Left Ventricular Lead Placement In CRT Recipients” Journal Of Interventional Cardiac Electrophysiology. 2014 Dec;41(3):211-5. doi: 10.1007/s10840-014-9953-4 Epub 2014 Nov 13

Saba S; Alam, MB; Adelstein, E; Schwartzman, D; Jain, S; Gorcsan III, J “Echocardiography-Guided Left Ventricular Lead Placement For Cardiac Resynchronization Therapy In Ischemic Vs Nonischemic Cardiomyopathy Patients” Heart Rhythm. 2014 Apr;11 (4):614-9. PMID: 24462657

Daya HA, Alam MB, Adelstein E, Schwartzman D, Jain S, Marek J, Gorcsan J, Saba S. “Effect Of Echocardiography-Guided Left Ventricular Lead Placement For Cardiac Resynchronization Therapy On Mortality And Risk Of Defibrillator Therapy For Ventricular Arrhythmias In Heart Failure Patients (From The Speckle Tracking Assisted Resynchronization Therapy For Electrode Region [Starter] Trial)” The American Journal Of Cardiology 113, no. 9 (2014): 1518-1522.PMID: 24630387

Adelstein E, Alam MB, Schwartzman D, Jain S, Marek J, Gorcsan J, Saba S “Misclassification Of Pulmonary Hypertension Due To Automated Pulmonary Capillary Wedge Pressure Calculations” The Federation Of American Societies For Experimental Biology Journal 28, no. 1 Supplement (2014): 1089-1

Shterental S, Anthony Longhini A, Alam MB, Bachman T, Corotto P, Gupta S, Nguyen D, Shoushtari A, Zaidi F, Simon M, Champion HC “Augmentation Area Index: A Novel Approach To Disease Severity And Outcome In Patients With Who Group I And Group Iii Pulmonary Hypertension” The Federation Of American Societies For Experimental Biology Journal 28, no. 1 Supplement (2014): 1089-2

Shterental S, Alam MB, Bachman T, Corotto P, Gupta S, Nguyen D, Sciurba F, Simon M, Champion HC “Battery Longevity In Cardiac Resynchronization Therapy Implantable Cardioverter Defibrillators” Europace. 2013 Oct 6. doi:10.1093/europace/eut301 PMID: 24099864

Alam MB, Munir MB, Rattan R, Flanigan S, Adelstein E, Jain S, Saba S “A Fatal Case Of Naficillin – Induced Hepatotoxity: Case Report And The Literature Review “ Case Reports in Medicine, vol. 2012, article id 953714, 3 pages, 2012 doi:10.1155/2012/953714. PMID: 22844299

Alam MB, Kadoura A, Sathaiah M “Frequency And Characteristics Of Skin Cancers Diagnosed At Ayub Medical College, Abbottabad Pakistan From 1995-2003” Journal of Ayub Medical College Abbottabad. 2007 Dec; 19(4): 3-7. PMID: 18693585

Ahmed A, Alam MB, Khan W, Badar A, Shah SH: “Situs Inversus Totalis With Dextrocardia And Liver Abscess.” KUST Med J 2009; 1 (1): 21-23

Leef G, Qin D, Alam MB, Rattan R, Munir MB, Patel D, Khattak F, Vaghasia N, Jain SK, Saba S: “Physician Adherence To Published Guidelines In Prescribing Anti-Arrhythmic Medications In The Management Of Atrial Fibrillation” Journal of the American College of Cardiology. 2015;65(10_S):. doi:10.1016/S0735-1097(15)60387-4

Adelstein, E. C, Alam, M. B., Schwartzman, D, Jain, S, Gorcsan, J, & Saba, S “Effect Of Echocardiography-Guided Left Ventricular Lead Placement For Cardiac Resynchronization Therapy On Mortality And Risk Of Defibrillator Therapy For Ventricular Arrhythmias In Heart Failure Patients (From The Speckle Tracking Assisted Resynchronization Therapy For Electrode Region [Starter] Trial)” Journal of the American College of Cardiology 63, no. 12_S (2014):